Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. Then just as Meredith and Derek grow more intimate, a surprise is revealed. Picks up where the last episode left off. Meredith attempts to work with Addison Shepard. George is pimped out to relay the hospital gossip back to Webber. Meredith and Cristina relate at Emerald City Bar about what dating their respective attendings is like.
Cristina ponders her relationship with Burke while trying to make a decision. Meredith is devastated by the latest blow to her love life. Meanwhile, Joe the bartender collapses. There's tension between Meredith and Addison. We find out why Derek and Addison aren't together. Bailey puts George on an impossible case. The rest of the interns operate on a family that was just in a car accident. Cristina and Meredith try to figure out if Cristina should tell Burke that she's pregnant right before Cristina faces an emergency.
Alex and Izzie get closer while Meredith's mother gets too close. As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn't improve her demeanor any. And Meredith's mother, Dr. Ellis Grey, has the hospital staff running in circles. Cristina goes right back to working right after being discharged.
Izzie isn't talking to Alex. Derek and Meredith treat a patient. George and Alex get stuck in an elevator. Train Wreck victims come to Seattle Grace and all staff gets called in. Everyone deals with really weird cases. Except Addison and Izzie. They work with a woman who is pregnant. Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascination among the staff.
George relates to a patient's husband. Meredith tries to avoid the Shepherds. Cristina and Burke go out on a date and end up getting caught up in their jobs.
Derek asks Meredith not to ignore him until Addison comes walking around the corner. It's Thanksgiving at Seattle Grace Hospital but the holiday's festivites are less than in order. Meredith and Derek try to counsel a family after their relative has had a seriously traumatic accident.
Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term of 36 weeks. All the departments are on call for the quintuplets as three of them have developped problems of different kinds.
Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position. Alex and Derek must take care of a patient who has a tumor inducing thirst as a side effect. On the love side, Alex and Izzie are having some slight sexual problems, while Meredith goes on adding one night stands and Cristina is thrown off course by being "keyed. Cristina Yang has little sympathy for Constance Ferguson special guest star Rosanna Arquette , a prison inmate who jeopardizes her health just to get out of solitary confinement.
Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson. The holiday season has started but not everyone is in a festive mood. This is Alex's last day in the hospital unless he passes his boards practical exam the next day, thus everyone helps him to review so that he succeeds.
However, Izzie is not happy about the others helping him and Meredith has to remind her of the true spirit of the Christmas holiday. Justin is in need of a new heart. One is available but he does not want it because he does not believe Santa gave it to him as his mother said. Cristina and Burke, both handling Justin's case, have opposing views on the matter due to their different stances on religion. Despite a reconciliation with his wife, Derek isn't in a festive mood.
George has a simple case of a woman who has a bleeding ulcer, he realizes that the ulcer is caused by her entourage but fails to keep them away, with the consequence that it perforates. Cristina is bothered by a new year's mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. Addison detests Derek's trailer, Derek visits Meredith's mom, George treats a young teen hermaphrodite frustrated by her pre-pubescence.
Other news includes patients doing uncanny things and relationship havoc being wrecked between the doctors, as per usual. Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task to expel a discharged and defiant woman from the hospital. Alex learns his fate after re-taking his medical exams. At the same time Izzie is trying to stop Alex from making stupid decisions when a patient that doesn't speak English is lied to by her coach.
George, Cristina, and Alex compete in a hot dog eating competition. All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr.
Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR. An explosive case arrives at the O.
Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat. Derek is still operating when he finds out about Meredith's current situation.
Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse. Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff.
Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding.
Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family in fact maybe more than she may have wanted to know through her parents. Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up.
Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle.
Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem. Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny.
Someone finds comfort in confiding in a patient who is going through an ordeal of his own. The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways that bother and creep out Cristina, Cristina gets stuck on diaper duty, Bailey gets involved in a case even though she's still supposed to be on maternity leave, Addison and Derek have a talk, and Izzie is still flaking on Alex for Denny Duquette, the heart patient who didn't get a heart.
In the patients-of-the-week department we've got a very pregnant woman, a hockey player who desires medically unnessasary amputation, and a woman with a fork in her neck who happens to be dying and has a struggling marriage. After a series of deaths at the hospital some of the staff become very superstitious.
Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina crazy. Derek and Addison discuss their relationships with Meredith. Richard treats a friend from 17 years ago who reveals a secret about a dark time in his past that involves Ellis.
George gets an earful about the women he's not talking to. Burke and Cristina argue about kicking George out. Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother.
Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke.
George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships.
Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives. Derek treats a divorce attorney who asks if Derek is in need of her services.
While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best. Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary jazz musician refuses to see medical reason. The musician is Burke's musical hero. Finn makes Meredith breakfast.
The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating. The pregnant woman is named Melanie and she will die but her baby may survive.
One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas.
Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates. Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith. George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie.
A week pregnant girl dies in the O. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients. Finn is still treating Doc for medical problems. Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.
This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie and George have a talk about his feelings. Meredith and Derek have a talk about Doc. Meredith must make an important choice about which path she wants to follow to determine the future of her love life.
While she considers her future she and others have flashbacks of their pasts. Cristina spends time with Burke while he recovers. Webber and Adele have a conversation after he spends the night at the hospital.
Everyone attempts to deal with Izzie's choice to quit. George seeks relationship advice from Derek. Cristina meets Burke's parents, the interns try to get Izzie's job back, and Addison takes a day off, a surgical patient may be living her last day. Some of the interns want to know why Bailey won't talk to Izzie. Meredith tries to decide between Derek and Finn and comes to a decision somewhat.
Webber finds out that Callie has been living in the hosiptal and he confronts her about it. The staff tries to prevent a patient from getting an elective surgery. Cristina tries to help Preston cope with the after effects of his surgery.
A patient bails on their surgery. Someone goes to a bed-and breakfast. Alex deals with a patient who has had a high amount of injuries in the past. A man undergoes surgery. Before the surgery his wife was only somewhat supportive, but the results may be too much for her to handle.
Izzie tries to go back to the hospital for the first time since Denny died. One child's constant visits are noted by a nurse. Two foster patients are met with suspicions of child abuse. George and Callie's relationship moves forward. Shawn Sullivan, a car salesman who just had surgery, wants to get back to his routine so he doesn't lose his renown. Addison works with a pregnant woman named Rebecca who may need a C-section and Addison doubts her medical skills.
Rebecca wants to have the baby naturally. Derek and Mark's opinions clash when the try to decide the course of treatment for a burn victim. Izzie gets surprised. Cristina pushes Burke to get better faster. Derek learns one of Addison's secrets. Bailey talks about motherhood and depression to a mother who is set to have cancer surgery and who seems to not care about any decisions concerning the future.
A resident is fiercely questioned about the death of a male patient. An ex-couple meet before lunch and get stuck - Meredith and Addison work on their case. Things get awkward when the ex-couple's daughter, Michelle, arrives at the hospital. Cristina gets to scrub in on a rare surgery which incites envy. Alex questions his future in plastics. George and Addison work together with Noelle. Noelle is pregnant with twins but one of them is growing slower than the other.
Derek's sister visits. A patient's wife makes things hard on the staff since she has made her husband's health her job. A woman's sexual exploits are questioned. The men of Seattle Grace go on a camping trip together, Addison and Callie must team up to work on a patient, Meredith assists Sloan with a procedure unlike any she has experienced, and, suspicious of her recent actions at the hospital, Bailey confronts Cristina.
A 9-year-old is seen by Cristina after he swallowed Monopoly game pieces. A pregnant year-old, is brought in after she slipped in the shower. Game of Thrones' watch has ended, Fleabag raised an eyebrow to us for the last time, Crazy Ex-Girlfriend took its final bow, and The Big Bang Theory finally fixed that dang elevator.
The last 12 months brought fans of some of television's biggest s… Read more. Cristina babysits for Bailey and doesn't take to it well at all; Addison and Derek come to terms with their relationship; and heart patient Denny Duquette Jeffrey Dean Morgan keeps coming between Alex and Izzie. Natalie Cole guest stars. A rash of deaths at Seattle Grace brings out the doctors' superstitious sides, especially Izzie, who fears the worst about Denny's surgery. Meanwhile, a young Amish woman Jessica Stroup with cancer must choose between her parents and her best friend Rachel Boston , who has been shunned by her community back home.
As Cristina weighs her marriage proposal, Ellis Kate Burton experiences a change in her medical condition; and a surgical patient endangers the lives of her surgeons when her blood becomes toxic. The beginning of a three-part story arc in which a ferryboat disaster poses stern challenges to the interns. Meanwhile, Cristina has trouble telling Meredith that she and Burke are engaged; and Sydney Kali Rocha decides she wants to be chief resident.
Meredith remains missing after falling into the water at the site of the ferry disaster, where Izzie must perform delicate brain surgery on the fly while taking instructions from the chief over the phone. Back at the hospital, Alex struggles to match unidentified victims with anxious family members while George searches frantically for a 7-year-old boy after telling his injured mother he was safe just before she went into surgery.
As Bailey, Burke, Addison and the chief work feverishly to save her life, Meredith receives affirmation from an unexpected source. Dylan: Kyle Chandler. Denny: Jeffrey Dean Morgan. Bonnie: Monica Keena. Liz Fallon: Anna Maria Horsford. The race for chief heats up as a new competitor enters the race; tensions mount between Izzie and George; Callie must reveal a big secret; Derek treats a patient close to him; and Alex continues his work with Jane Doe Elizabeth Reaser.
Helen Crawford: Shohreh Aghdashloo. George meets his new father-in-law Hector Elizondo , but is in no condition to make a good impression; Alex helps Jane Doe Elizabeth Reaser determine how she'll look from now on; the hospital board interviews candidates for the chief's position; and Izzie wrestles with a startling revelation about a close friend. Doug Kendry: Michael Boatman.
Cathy Rogerson: Catherine Dent. Colin Marlow: Roger Rees. George comforts Izzie as she faces her painful past; Derek questions his relationship with Meredith while she must decide what sort of relationship she'll have with her stepmother Mare Winningham ; and Cristina decides to fight for her relationship with Burke, despite her history with Colin Marlow Roger Rees.
Joan Waring: Dee Wallace. While the interns cram for an exam, the attendings jockeying to succeed Webber as chief offer the very best of care to a very important patient: the hospital's board chair. Meanwhile, Burke plans his wedding without much help from Cristina; things heat up between Alex and Addison; and Derek questions his relationship with Meredith.
Larry Jennings: Mitch Pileggi. Sydney Heron: Kali Rocha. Jane Doe: Elizabeth Reaser. Addison takes a leave of absence to visit old medical-school friends in Los Angeles; Meredith's stepmother Mare Winningham arrives at the hospital with hiccups; and Cristina reluctantly plans her wedding, with the help of her mother Tsai Chin and Burke's mom Diahann Carroll.
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